Zahlavi

Selection Procedures

Postdoctoral Research Fellow in Microfluidics

The Institute of Photonics and Electronics v. v. i., in accordance with the Act No. 283/1992 of the Academy of Sciences of the Czech Republic, as amended by the Act No. 420/2005, and in accordance with the Statutes of the Academy of Sciences of the Czech Republic, invites applications for a Postdoctoral Research Fellow position in the field of Microfluidics.

Our research team Optical Biosensors (team leader Prof. Jiří Homola) is currently looking for a postdoc research fellow in the field of microfluidics.

Do you want to use your theoretical knowledge of microfluidics as well as the ability to create microfluidic devices? Are you interested in projects in which you can work closely with experts in the fields of optics, photonics, chemistry or biology and contribute to the development of new optical biosensors? Are you eager to see your microfluidic systems being used in molecular biology or medical diagnostics? If your answer is yes, you should apply for this position!

Job description

The development of microfluidic systems for optical affinity biosensors based on surface plasmons.

Specific tasks include:

  • modelling, design and implementation of microfluidic chips for the detection of biomolecules and cells and for the study of biomolecular interactions,
  • characterization of microfluidic chips and devices,
  • design and implementation of experiments and data analysis.

Requirements

  • Ph. D. degree in engineering, chemical engineering, physics, chemistry, or in related field,
  • experience in research and development of microfluidic systems,
  • experience in fabrication of microfluidic structures and devices, and knowledge of micro-/nanofabrication methods,
  • publication record in the field of microfluidics,
  • experience in simulations and programming languages (e.g. Matlab),
  • experience in computational fluid dynamics (CFD) is of advantage,
  • experience in collecting and analyzing affinity-based biosensor data is of advantage.

We offer

  • interesting and challenging work in an international research team,
  • work on multidisciplinary scientific projects with real-world impact,
  • excellent research infrastructure including a wide range of micro- and nano-fabrication methods,
  • language and professional training courses,
  • 5 weeks of vacations,
  • sport allowance (Multisport card).

Terms of employment

Full-time employment contract for 2 years (with the possibility of an extension) starting from May 2020 or as soon as possible thereafter.

Application procedure

If you find this position interesting, respond to Mrs. Jana Petrlova (e-mail: petrlova@ufe.cz) with the following documents:

  • cover letter,
  • CV,
  • list of publications.

In the subject line of your e-mail, please state that you apply for the position of Postdoctoral Fellow in the field of Microfluidics.

Deadline: 31. 03. 2020


In order to conduct the selection procedure on the position you are applying for it is necessary to collect and process your personal data. By replying to this ad, you provide to the Institute of Photonics and Electronics, Czech Academy of Sciences (located at Chaberská 57, 18251, Praha 8, Czech Republic) your personal data only for the purpose of the selection process. The personal data shall be stored for the duration of the selection procedure, and further for max 6 months after the termination of the selection procedure for the legitimate interest of the controller in order to prove the proper course of the selection procedure and to evaluate the results of the selection procedure. During metioned period personal data can be stored on our internal and an external storage (owned by Microsoft Corp.) with dedicated access. After the above period expires, your personal data will be permanently deleted.

Postdoctoral Research Fellow in the field of Functional Coatings for Optical Affinity Biosensors

The Institute of Photonics and Electronics v. v. i., in accordance with the Act No. 283/1992 of the Academy of Sciences of the Czech Republic, as amended by the Act No. 420/2005, and in accordance with the Statutes of the Academy of Sciences of the Czech Republic, invites applications for a Postdoctoral Research Fellow position focusing on the development of functional coatings for affinity optical biosensors.

Our research team Optical Biosensors (team leader Prof. Jiří Homola) is currently looking for postdoc research fellow focusing on the development of functional coatings for optical affinity biosensors.

Do you want to use your knowledge and experience in the preparation of functional materials and coatings? Do you want to develop advanced surfaces for investigation of molecular systems, medical diagnostics or environmental monitoring? Are you enthusiastic about multidisciplinary projects in which you can work closely with experts from various disciplines (chemistry, biology, photonics, or microfluidics) and develop new optical biosensors? If your answer is yes, you should apply for this position!

Job description

The selected candidate will carry out research and development of functional coatings for optical affinity biosensors.

Specific tasks include:

  • development of advanced functional surfaces (e.g. based on zwitterionic polymers or photoactivatable systems) for affinity biosensors based on photonic micro- and nano-structures,
  • preparation and characterization of developed functional surfaces,
  • use of functional surfaces for the study of biomolecular interactions and detection of biomolecules related to medical diagnostics and environmental monitoring.

Requirements

  • Ph. D. in organic chemistry, macromolecular chemistry, physical chemistry, chemical engineering or similar,
  • publication record in relevant field of material sciences,
  • experience in research and development of functional coatings for affinity biosensing is of advantage,
  • experience with the development and characterization of nanomaterials and nanostructures is of advantage.

We offer

  • interesting and challenging work in an international research team,
  • work on multidisciplinary scientific projects with real-world impact,
  • excellent research infrastructure,
  • language and professional training courses,
  • 5 weeks of vacations,
  • sport allowance (Multisport card).

Terms of employment

Full-time employment contract for 2 years (with the possibility of an extension) starting from May 2020 or as soon as possible thereafter.

Application procedure

In order to apply, please, respond to Mrs. Jana Petrlova (e-mail: petrlova@ufe.cz) with the following documents:

  • cover letter,
  • CV,
  • list of publications.

In the subject line of your email, please, state that you apply for Postdoctoral research fellow position in functional coatings for affinity optical biosensors.

Deadline: 31. 03. 2020


In order to conduct the selection procedure on the position you are applying for it is necessary to collect and process your personal data. By replying to this ad, you provide to the Institute of Photonics and Electronics, Czech Academy of Sciences (located at Chaberská 57, 18251, Praha 8, Czech Republic) your personal data only for the purpose of the selection process. The personal data shall be stored for the duration of the selection procedure, and further for max 6 months after the termination of the selection procedure for the legitimate interest of the controller in order to prove the proper course of the selection procedure and to evaluate the results of the selection procedure. During metioned period personal data can be stored on our internal and an external storage (owned by Microsoft Corp.) with dedicated access. After the above period expires, your personal data will be permanently deleted.

New postdoctoral position in molecular regulation of neural development

The Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic opens a position in the Department of Molecular regulation for a:

New postdoctoral position in molecular regulation of neural development

The laboratory was established at the Institute of Physiology (IPHYS), Prague in 2014 by Dr. Martin Balastik (Ph.D. at the Max-Planck institute for Biophysical Chemistry, Gottingen, Germany; postdoc Harvard Medical School, BIDMC, Boston, USA). IPHYS is a leading institute in the field of biomedical research in the Czech Republic located at the biggest biomedical research campus in the Czech Republic, only 30 min away from the historical center of Prague. We study molecular regulation of neural development, in particular the role of microtubule-associated proteins (MAPs) and prolyl isomerases in axon/dendrite guidance and synapse refinement, and how developmental deregulation of these genes contribute to pathogenesis of neurodevelopmental disorders (as autism spectrum disorder, epilepsy or schizophrenia). The laboratory uses an array of advanced mouse genetic, molecular biology, biochemistry and microscopy techniques, including generation of knockout mice, in utero electroporation, neuron cultures in microfluidic chambers, organotypic slice cultures, lentiviral vector cloning and production, confocal microscopy, super resolution microscopy and advanced image analysis (Neurolucida, Imaris).

Position offered

Following our recent discoveries demonstrating a novel role of CRMP2 in axon and dendritic spine refinement (Ziak et al, EMBO Rep. 2019, Balastik et al, Cell Rep. 2015), we are seeking a postdoctoral researcher with a PhD in molecular biology, neuroscience, biochemisty and related subjects to analyze the role of microtubule associated proteins of CRMP (collapsing response mediator protein) gene family and their isoforms in actin-microtubule crosstalk in growth cones and dendritic spines.

The position is offered for 3 years with a possibility for extension, and provides the candidate with a competitive salary and benefits.

Project annotation

Dendritic spines are microscopic protrusions found on neuronal dendrites, which interact with terminal boutons of axons to form synapses. Morphology and number of dendritic spines have a direct effect on synaptic transmission. Changes of density, size and shape of dendritic spines have been linked to multiple neurodevelopmental disorders (e.g. autism and schizophrenia). The morphology of dendritic spines is mainly controlled by actin microfilaments, similarly as the shape of the tips of the growing axons – the growth cones. Molecular mechanisms controlling formation, maintenance or elimination of dendritic spines and rearrangement of growth cones are so far poorly understood.

We have recently demonstrated a novel mechanism regulating axon growth and guidance in vivo through phosphorylation and conformational changes of microtubule associated protein CRMP2 catalyzed by isomerase Pin1 (Balastik et al, Cell Rep, 2015). In order to better characterize the role of CRMP2 in development, we generated and analyzed full- and isoform specific- CRMP2 knockout mice. Surprisingly, we found that in contrast to previously published in vitro data, CRMP2 plays in vivo only a moderate role in embryonic axon guidance, but that it is essential for synapse refinement through processes of axon and dendritic spine pruning (Ziak et al., EMBO Rep, 2019). In addition, we found that CRMP2 deficiency leads to changes of dendritic spine morphology suggesting that CRMP2 is important for regulation of not only microtubules (as demonstrated before), but also actin microfilaments. Actin – microtubule crosstalk is essential for development and function of dendritic spines and growth cones. The successful postdoctoral candidate will test isoform-specific binding of different CRMPs to actin and how they control actin-microtubule crosstalk in dendritic spines and growth cones in vitro and in vivo. The role of CRMP phosphorylation in CRMP-actin interaction will be analyzed in primary neurons and in vivo using the in utero electroporation.

Application

Interested candidates can send their application to email: Marcela.Tomaskova@fgu.cas.cz

References

  • Ziak J, et al., CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling, EMBO Reports, (2019) accepted, BioRxiv DOI: 10.1101/719617
  • Balastik, M, et al, Prolyl isomerase Pin1 regulates axon guidance by stabilizing CRMP2A selectively in distal axons. Cell Reports 2015 Oct 27;13(4):812-28

Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 142 20 - Prague 4, Czech Republic.

Deadline: 31. 03. 2020


By replying to this advertisement (or by sending a CV), the job seeker acknowledges that, in connection with the ongoing selection procedure for a particular job position, the Institute of Physiology of the Academy of Sciences of the Czech Republic, v.v.i., is processing personal data.

Mandatory information related to the processing of personal data is available at www.fgu.cas.cz

Postdoctoral position in Molecular Physiology of Bone

The Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic opens a position in the Department of Molecular Physiology of Bone for a:

Postdoctoral position in Molecular Physiology of Bone

A Postdoctoral position is available in the laboratory of Dr. Michaela Tencerova (Ph.D. at Charles University in Prague, Czech Republic, Postdoc at University of Massachusetts, Worcester, USA and University of Southern Denmark, Odense, Denmark) at the Institute of Physiology (IPHYS) Prague. IPHYS is a leading research institute in the field of normal and pathological physiology. It consists of a number of scientific and service department and shared equipment for the research (http://www.fgu.cas.cz/en/). IPHYS is also connected with the centers of excellence and is the partner of excellence project BIOCEV (including Mouse genotyping center) carried out jointly with other Academy of Sciences’ institutes and Charles University in Prague.

The research in the laboratory of Dr. Michaela Tencerova is focused on studying the physiological role of bone marrow adipose tissue in relation to bone and fat metabolism in metabolic complications. The research continues on our previous studies identifying different metabolic phenotype of bone marrow adipocytes comparing to peripheral adipose tissue in obesity (Tencerova et al, Cell Reports, 2019; Tencerova et al., Bone Res, 2019; Tencerova et al., JBMR 2018). The successful applicant will work with murine and human cellular systems (bone marrow skeletal stem cells) and animal transgenic models applying high-throughput methods such as RNA sequencing, metabolomics, lipidomics, and bioenergetics. The research will be conducted in collaboration with prestige national and international laboratories in USA and Europe.

Requirements:

We are looking for:

  • Highly motivated, independent, creative candidates with Ph.D. degree (with up to 8 years from Ph.D.) in molecular biology, biochemistry, physiology, medicine, pharmacology or related disciplines;
  • advanced experience with molecular biology techniques, in vitro cell culture methods, cloning, animal work (metabolic assays, drug administration etc.);
  • track record of scientific publications, capability of working in international team, great level of English in written and spoken form.

We offer:

  • Working in international environment
  • Competitive salary
  • Social benefits (health insurance, contribution to pension, diets, courses)
  • 6 weeks holiday + sick days

Further information:

The position is available from 1 January 2020 or soon thereafter. The project duration is two-three years with the possibility for extension.

Application:

Interested candidates can send their motivation letter and CV with the names and contact information of two-three references to email: Marcela.Tomaskova@fgu.cas.cz

Deadline: 31. 03. 2020

 

Post-doctoral or early career researcher in the Centre of Global Studies

Call for applications:
Post-doctoral
or early career researcher
in the Centre of Global Studies

Director of the Institute of Philosophy of the Czech Academy of Sciences announces a call for applications for a post-doctoral or early career researcher in the Centre of Global Studies.

Job description:

  • research in the field of global studies, focusing mainly on Asia or Latin America
  • publication of academic texts
  • presentation at conferences
  • popularization activity

We require:

  • Ph.D. in philosophy, sociology, international relations or related disciplines
  • good knowledge of English language and good knowledge of another language relevant for the given territorial area of ​​research
  • specialization in the field of research
  • willingness to present occasionally the results of research also to the wider public

We offer:

  • full time job at the Centre of Global Studies
  • fixed-term employment contract, with the possibility of extension
  • the salary corresponding to the CV and the Internal Wage Regulations of the Institute
  • the possibility to participate in unique academic projects
  • work in a prestigious public research institution
  • flexible working hours
  • pleasant working environment
  • employee benefits (25 days of holiday a year, 8 sick days, language courses and yoga at the workplace)
  • start from July 1, 2020 or by agreement

Documents required for application:

  • structured CV
  • cover letter
  • scanned copy of PhD. diploma
  • contact information for at least two referees

Please send your application by March 31, 2020 by e-mail to cgs@flu.cas.cz or by standard mail to: Institute of Philosophy, Czech Academy of Sciences, Director's Secretariat, Jilská 1, 110 00 Prague 1, Czech Republic, EU.

The selected candidates will be invited to an interview (in person or online) in April 2020.

Contact person: Ms. Marie Hlavičková, phone: +420 221 183 350, e-mail: cgs@flu.cas.cz


By submitting your application, you give the Institute an automatic consent to the processing and storage of your personal data for the purpose of applying for a job in the Institute in accordance with the General Data Protection Regulation 2016/679 (GDPR). The consent may be withdrawn at any time.

Technician position in organic chemistry at IOCB Prague

Job Description

A chemist position in Targeted research group HBV Cure (head Gabriel Birkuš, Ph.D.) is available for a highly motivated and creative scientist with expertise in organic chemistry. The project is focused on the identification of novel cGAS inhibitors.

GMP-AMP synthase (cGAS) serves as a sensor of cytosolic dsDNA and plays an essential role in innate immunity against viral/bacterial infection and cellular damage. Upon binding of dsDNA, cGAS synthesizes a cyclic dinucleotide 2’3’cGAMP that serves as a second messenger and initiates an inflammatory cellular response. Uncontrolled activation of the cGAS pathway has been implicated in autoimmune and autoinflammatory diseases such as Aicardi-Goutieres syndrome or Systemic Lupus Erythematosus. Thus, inhibition of cGAS may be of therapeutic benefit in some diseases.

The successful candidate will be a member of a multidisciplinary team and be involved in our efforts to identify novel cGAS inhibitors. He or she will be responsible for the synthesis of target compounds. The candidate will also have a unique opportunity to experience the lead optimization process of drug development. An attractive salary and an opportunity to work with clinical candidates guaranteed.

Requirements

The applicant must have an M.Sc. degree in organic chemistry. We are looking for independent applicants with basic knowledge of synthetic organic chemistry and standard purification techniques. Good oral and written communication skills in English are required.

We offer

  • 5 weeks holiday
  • 3 sick-days
  • meal allowance
  • contribution to supplementary pension savings
  • other employee benefits

The position is available starting from now.

Please submit your resume, motivation letter, and contact information by e-mail to Ondřej Páv, Ph.D. at ondrej.pav@uochb.cas.cz

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences / IOCB Prague is a leading internationally recognized scientific institution whose primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. An integral part of the IOCB Prague’s mission is the implementation of the results of basic research in practice. Emphasis on interdisciplinary research gives rise to a wide range of applications in medicine, pharmacy, and other fields.

Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague
Flemingovo n. 542/2
166 10 Prague 6
Czech Republic

Postdoctoral position in organic chemistry at IOCB Prague

Job Description

A postdoctoral position in Targeted research group HBV Cure (head Gabriel Birkuš, Ph.D.) is available for a highly motivated and creative scientist with expertise in organic chemistry. The project is focused on the identification of novel cGAS inhibitors.

GMP-AMP synthase (cGAS) serves as a sensor of cytosolic dsDNA and plays an essential role in innate immunity against viral/bacterial infection and cellular damage. Upon binding of dsDNA, cGAS synthesizes a cyclic dinucleotide 2’3’cGAMP that serves as a second messenger and initiates an inflammatory cellular response. Uncontrolled activation of the cGAS pathway has been implicated in autoimmune and autoinflammatory diseases such as Aicardi-Goutieres syndrome or Systemic Lupus Erythematosus. Thus, inhibition of cGAS may be of therapeutic benefit in some diseases.

The successful candidate will be a member of a multidisciplinary team and be involved in our efforts to identify novel cGAS inhibitors. He or she will be responsible for the synthesis of target compounds. The candidate will also have a unique opportunity to experience the lead optimization process of drug development. An attractive salary and an opportunity to work with clinical candidates guaranteed.

Requirements

The applicant must have a Ph.D. in organic chemistry. We are looking for independent thinkers with excellent expertise in synthetic organic chemistry, and with knowledge of analytical and spectroscopic methods. Experience in medicinal chemistry is an advantage. Good oral and written communication skills in English are required.

We offer

  • 5 weeks holiday
  • 3 sick-days
  • meal allowance
  • contribution to supplementary pension savings
  • other employee benefits

The position is available starting from now.

Please submit your resume, motivation letter, and contact information by e-mail to Ondřej Páv, Ph.D. at ondrej.pav@uochb.cas.cz.

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences / IOCB Prague is a leading internationally recognized scientific institution whose primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. An integral part of the IOCB Prague’s mission is the implementation of the results of basic research in practice. Emphasis on interdisciplinary research gives rise to a wide range of applications in medicine, pharmacy, and other fields.

Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague
Flemingovo n. 542/2
166 10 Prague 6
Czech Republic