Výběrová řízení
Ústav fyzikální chemie J. Heyrovského AV ČR, v. v. i. vyhlašuje v souladu se zákonem č. 283/1992 Sb. o Akademii věd České republiky, ve znění zákona č. 420/2005 Sb. a Stanov AV ČR výběrové řízení na pozici PhD position in computational biophysics and biomolecular modeling.
The Timr group at the J. Heyrovský Institute of Physical Chemistry in Prague offers a PhD position in computational biophysics and biomolecular modeling.
Are you fascinated by the complexity of the interior of living cells? Do you enjoy constructing models of proteins and other biomolecules in the computer? Would you like to use the tools of physics, chemistry, and mathematics to describe processes in cells?
Our research group focuses on the computer simulation of the cell interior. Using multi-scale computational models, we aim to elucidate the physical and chemical mechanisms governing the organization of metabolic pathways in living cells. Supported by the Lumina Quaeruntur Award and a grant from the Czech Science Foundation, our team is integrated into the interdisciplinary Department of Computational Chemistry. This department bridges the physical chemistry and biophysics of proteins and membranes with theoretical enzymology and spectroscopy.
PhD project: Computational modeling of dynamic enzyme assemblies
In living cells, various enzymes have been found to assemble into transient structures, appearing and disassembling in response to external conditions. Such dynamic enzyme assemblies, identified in processes like glycolysis and purine synthesis, play an important role in regulating cellular metabolism. They potentially act as switches between competing metabolic pathways. However, the mechanisms behind the formation and functionality of these assemblies are yet to be fully elucidated. This project will explore dynamic enzyme assemblies through a combination of atomistic, coarse-grained, and kinetic modeling, closely integrated with experimental data. The student will characterize the molecular interactions that promote assembly formation and investigate how the crowded environment within these assemblies impacts the transfer of substrates between consecutive enzymes in a pathway. The computational methodologies developed in this work will serve as a basis for the prediction of metabolic fluxes from the composition and architecture of a dynamic enzyme assembly. Thus, the project will enhance our understanding of the regulation and control of metabolic pathways in cells, offering insights into their adaptability and efficiency.
Starting date: Summer 2023 (no later than October 1)
Type of contract: Temporary
Job status: Full-time
Requirements:
The candidates are expected to hold an MSc (or an equivalent) in physics, chemistry, or a related field before the start of the position. They should be interested in biomolecules, capable of formulating mathematical models, and motivated to learn new things. Moreover, they should possess good computer skills and be fluent in English. Experience with molecular simulations and programming will be a plus. The successful candidates will enroll at Charles University in Prague, the top-ranking university in the Czech Republic.
We offer:
- 5 weeks paid leave of absence (holidays) per year + 3 days of paid sick-leave in addition to the statutory insurance
- Flexible working-time, the possibility of part-time work
- Lunch vouchers
- Possibility of attending children groups of the CAS
- Sports goods rental, free parking, trade union library
- Language courses
- Possibility of further education and career development by participating in courses organized by our institute.
Eligibility criteria:
To apply, please send your CV, a motivation letter, transcripts of all courses and grades, and contact information for two references to recruitment@jh-inst.cas.cz and stepan.timr@jh-inst.cas.cz. In your motivation letter, please explain how the proposed research aligns with your interests and why you believe you are a good fit for the position. Please include SC2024_12 in the email subject line. For any inquiries, contact stepan.timr@jh-inst.cas.cz.
By providing us with your personal data in your CV, you have allowed J. Heyrovský Institute of Physical Chemistry to process and file your CV in the HR database. Your personal data will be used for the internal HR needs of the J. Heyrovský Institute of Physical Chemistry only. At the same time, you confirm here that the personal data as stated in the CV you have sent to us is true and accurate.
Uzávěrka přihlášek: 02. 04. 2024
Dovolujeme si Vás informovat, že zasláním odpovědi na inzerát poskytujete příslušnému správci své osobní údaje, a to za účelem realizace výběrového řízení a uzavření pracovní smlouvy nebo dohody (DPP, DPČ) ohledně Vámi vybrané pozice. Toto zpracování Vašich osobních údajů bude prováděno na právním základě splnění smlouvy dle 6 odst. 1 písm. b) obecného nařízení o ochraně osobních údajů (GDPR). Vaše osobní údaje budou zpracovávány pouze v nezbytném rozsahu a pouze po dobu trvání výběrového řízení na danou pozici. Zpracování Vašich osobních údajů bude dostatečně zabezpečeno, Vaše osobní údaje nebudou bez Vašeho souhlasu předávány třetím osobám. V souladu s příslušnými právními předpisy Vás informujeme, že máte právo (i) na přístup k osobním údajům, (ii) na opravu či doplnění nepřesných nebo nepravdivých osobních údajů, (iii) na výmaz osobních údajů, (iv) na omezení zpracování osobních údajů ve zvláštních případech, (v) na přenositelnost údajů, (vi) vznést námitku proti zpracování a (vii) obrátit se na Úřad pro ochranu osobních údajů.