A link between autoimmune disorders and tooth enamel defects revealed
07. 12. 2023
In a groundbreaking study published in Nature, an international team of researchers has discovered a crucial link between autoimmune disorders and defects in tooth enamel development. This study sheds light on the poorly understood conditions of Amelogenesis Imperfecta in patients with Autoimmune Polyglandular Syndrome Type-1 (APS-1) and Celiac Disease.
Ameloblasts, the cells responsible for tooth enamel formation, rely on several proteins to create a durable outer layer for our teeth. When these proteins are attacked by the body's immune system, it leads to Amelogenesis Imperfecta, a condition characterized by weakened, discolored, and easily damaged teeth. This condition has long puzzled the medical community, but the new study led by Jakub Abramson from the Weizmann Institute in Israel offers unprecedented insights.
The research team, including notable contributions from Dr. Jan Prochazka from Czech Center for Phenogenomics, has utilized advanced technology to analyze tooth phenotypes, shedding light on the processes disrupting enamel mineralization in autoimmune conditions. The study reveals that most patients with APS-1 and Celiac Disease develop autoantibodies, particularly of the IgA isotype, against ameloblast-specific proteins. This results in a breakdown of the body's tolerance to these proteins, leading to compromised enamel formation. In Celiac Disease, this phenomenon appears to be linked to a loss of tolerance to intestinal antigens that are also present in enamel tissue. These findings suggest a novel type of IgA-dependent autoimmune disorder, which the researchers have collectively termed "autoimmune amelogenesis imperfecta."
The Czech Centre for Phenogenomics (CCP), at the Institute of Molecular Genetics, led by Radislav Sedlacek is a hub of excellence in genetic research, uniquely integrating genetic engineering, advanced phenotyping, and state-of-the-art imaging within a controlled animal housing environment. The CCP is renowned for its creation of sophisticated mouse and rat models, essential in dissecting genetic disorders and testing medical interventions. As an active member of global consortia like IMPC and INFRAFRONTIER, the CCP contributes to an international effort to map gene functions and their implications in human diseases.
- Front-flip: parasitic fish embryos must learn it when they are two days old
- Light-triggered chemistry in a single molecule
- Unique butterfly-shaped magnetic graphene nanoparticle combines two concepts of magnetism formation
- Altermagnetism has been experimentally confirmed
- Materials for reconstructive and plastic surgery improved
- Ethiopian highlands identified as the cradle of eastern afromontane shrew diversity
- A Czech to investigate how errors in genetic information arise thanks to prestigious grant
- The European Space Agency is preparing to return to Venus
- Insect wings may have evolved from gills
- Like baking bread: new insight into the behaviour of mud on Mars